Do you mean it is too awkward or you can't do it? I can do it but like everything else, I'm not used to it but I don't know yet if it is actually harder or just an adjustment to make.
But this brings up a problem I discovered. Fortunately, it turned out not to be with TB, but it is the reason I discovered it.
I have a programmable mouse where, using a Mac app called "steermouse", I can program buttons to sent keypresses to the computer. So one button enlarges text. Another makes it smaller. A third closes the active browser tab or window. So, unless I'm typing, my hands just stay on the mouse.
When starting with the TB, I found the buttons weren't working right. The problem was with how the Apple system works. I had created those buttons when the computer was set to Dvorak. But to use the TB and do Dvorak, I had to change the computer to qwerty. Well, apparently Apple properly adjusts the key strokes from the keyboard, but the mouse keystrokes changed when I went back to qwerty on the computer. So I had to edit them to work right.