I am using the new iPad Pro 10.5, after having used the big Pro first. The TB has become my single keyboard of choice across all my devices, and certainly helped to make my iPad much more of a production machine than it was before, even with an Apple keyboard - the TB's portability and ergonomics make it unbeatable. As for the iPad itself: with iOS 11 it's inching closer to being a full laptop replacement but I find there are still things that can be done better or more comfortable on a desktop or laptop machine (I use a MacBook Pro with an extra monitor attached). One obvious thing is having many windows open at once and freely moving between apps. That is getting easier in iOS 11, but the screen-estate is limited. I decided to drop the big iPad Pro because it didn't travel as well as the smaller one, but the smaller screen obviously has its limitations.
With the new Files app shaping up (it's far from complete in the current beta, but you can see where it's heading) I think one bit of awkwardness will soon be solved: that of exchanging documents between applications, and between the iPad and the outside world. The Files app will become a universal file sharing container over time. I have already seen several apps become integrated into the Files interface, which means you can now access their content from other apps, like mail, PowerPoint, Word, etc. without having to save them to one of your cloud drives first.
My only gripe is that Apple assumes one's Internet is always on, so there is no easy pathway to physically share files with the outside world, other than using a cloud drive of some sort. I happen to live in an Internet-poor country (rural Australia) and am also on the road quite a bit, so I often find myself in situations where I do not have (reliable) access to my cloud providers. Standard USB drives do not work - even when using a Lightning to USB converter. I personally use a USB flash-drive with a Lightning connector on one side, and a standard USB one on the other, but up to now, this drive (Adam Elements iKlips Duo) comes with its own app, which limits the way it integrates with the rest of iOS. It's useable, but still a bit of a workaround.
To make the iPad + TB totally awesome I am still looking for something that will hold up the iPad and the TB in a configuration I can use anywhere, including when sitting on a couch, chair, or even my suitcase when waiting to board a plane (something I do a lot). At the moment I am confined to using a flat surface such as a table top or bench, something that I do not always have access to when traveling. I have seen 'portable' desk solutions being sold online, but they look like they add a lot of bulk and weight to one's luggage, something I have been pushing back at. So, somebody, please, develop an iPad case that adds minimal weight and bulk, but provides some impact protection, Apple pencil storage, and TB-ready support so it can be used on my lap, in bed, on a couch, ... anywhere basically. That would truly make the iPad/TB combination the epitome of awesomeness.
Oh, by the way, the Apple pencil responsiveness on the new iPad is something you have to experience to believe. It is as close to using pen on glass (the glass is too smooth to make it feel like paper) as humanly possible. It's a joy to use.
I hope this helps.