There have been various tweeks people have made to suit their own needs or habits. Like some who change the Enter key to require another key like shift or space to do it’s thing. This way they avoid the problem of hitting it by accident.
But my thing here is about finding out if there are, at least generally, some customized ideas for certain needs. A prime example would be for gaming. I could easily see a benefit to having a layout designed to handle the needs of a typical game. Trouble is, while I like games, I don’t play enough different ones to have a good idea of what the basic needs would be. But even if some games need some specific tweaking, surely same basic things could be set up and then copied with the little adjustments for particular games.
Typical RPG is going to need movement keys for forward, back, etc. Maybe a standard item would be a key for moving forward, but press space and the same key (green layer) and you go faster.
Maybe some others here who do a lot of games can help create some basic game layouts? Or layouts for any other specific purpose. I know WT said the next version is expected to add some stuff to the number lock mode to make it work extra well with spreadsheets for example.