(content warning ... this will be a bit philosophical and whimsical. But true for me since it's how I think about things)
Interestingly, having a huge screen is tempting me in the opposite direction from where I have been going over the past few years.
In this big screen mode, I tend to think of cross-app “groupings” of windows. For instance on one virtual desktop I might have the mail app opened to a smart folder that just shows messages related to a certain project I am doing. And I might have a spreadsheet tile open, and a note from the notes app (you can double click to pop out a note from the app) and a focused todo list tile from my Things todo app, and a Chrome browser with tabs relating to that task, and maybe remote window into another computer. Then slide over to another virtual desktop for items relating to a different project. Of course I’m exaggerating in the number of different things on each desktop (usually!) but hopefully you get the idea. Then on my laptop screen I would keep a few general generic things always open such as my email inbox, slack, Skype, iPulse etc.
In recent years I moved away from this idea and started adapting a new way of thinking. I tried to have as much of my work as possible live in cloud or syncing apps or groupware. So I could leave certain things open on certain devices, or grab any device to read or work with something. The TextBlade is particularly enabling in this work mode because it makes all devices productive with the cross platform macros and jump capabilities. Also recent iOS has just (barely) gotten to the stage of being capable enough for this with it's 2-1/2 way multitasking (split screen, plus a popover app allowed) and more ios apps being fully featured rather than crippleware. It also means when I travel my workflow is essentially unchanged, there are just fewer total devices around me. Typically an iPad and iPhone only. But all devices everywhere are just interchangeable “views” into my online world; all different shapes and sizes and combinations.
Now with this monster screen I wonder whether the pendulum will swing back towards a CPU centric workflow. I’ll let the chips fall where they may and see what I naturally gravitate towards because in this scenario instead of my workflow feeling the same whether I’m traveling or at my office, it would feel distinctly inferior because I would be without my predetermined “environment” and infrastructure.